SOS N-Heterocyclic Carbenes in Catalytic Organic Synthesis 1

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SOS N-Heterocyclic Carbenes in Catalytic Organic Synthesis 1 | Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, Vol. 1" is an authoritative resource that delves into the rapidly evolving field of N-heterocyclic carbenes (NHCs) and their pivotal role in modern organic synthesis. Edited by esteemed chemists Steven P. Nolan and Catherine S.J. Cazin, this volume offers a comprehensive exploration of NHCs, from their fundamental architectures to their diverse applications in catalysis. The book begins by elucidating the basic principles of NHC chemistry, discussing their unique steric and electronic properties that have revolutionized catalyst design over the past two decades. It systematically covers the synthesis of NHC precursors, the carbenes themselves, and their corresponding metal complexes, providing readers with detailed methodologies and experimental procedures. A significant portion of the text is dedicated to the application of NHCs in various catalytic processes, including transition-metal catalysis and organocatalysis. The volume meticulously discusses metal- and non-metal-catalyzed reactions facilitated by NHCs, highlighting their efficiency in forming carbon–carbon and carbon–heteroatom bonds, C–H bond functionalization, and additions to carbon–carbon multiple bonds. Each chapter presents the current state-of-the-art methods, discussing the scope, limitations, and mechanisms of these reactions, complemented by key experimental procedures and typical examples of target synthesis. This structured approach not only showcases the utility of NHCs in synthesizing natural products and therapeutic agents but also inspires further applications and innovations in the field. Designed to serve both novices and seasoned researchers, this volume acts as a user's guide to NHC chemistry and catalysis, facilitating the introduction of NHCs to new practitioners while expanding the synthetic toolkit of experienced chemists. By providing a detailed overview of the most commonly used and significant NHC-catalyzed reactions, this work underscores the transformative impact of NHCs on the efficiency and versatility of organic synthesis., ISBN no:- 9783132012912, Author:- Nolan, Edition:- 1st Edition, Publication Year:- 2017, Publisher:- Thieme, Page No:- 548, Banding Types:- Hardcover, Replacement:- Returnable upto 3days (*T&C applied)